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Product Description
?-Nicotinamide mononucleotide (?-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+; . Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate ?-NMN, which is subsequently converted to NAD+ by ?-NMN adenyltransferase.1 At 50-100 µM, ?-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in ? cell function.2 Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.3
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