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Product Description
Characteristic: Common name?Hexapeptide-11 English name?Hexapeptide-11 CAS number?161258-30-6 Molecular formula?C 36 H 48 N 6 O 7 Molecular weight?676.80200 Accurate mass?676.35800 PSA ?201.71000 LogP?4.09300 Usage: Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts. Hexapeptide-11 reduces the appearance of fine lines and wrinkles, making this an excellent addition to all kinds of skin care and anti-aging products. It has a unique set of amino acids that help to manipulate collagen levels and boost elasticity in the skin. Exposure of fibroblasts to Hexapeptide-11 promoted dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses related genes. Moreover, it promoted increased nuclear accumulation of Nrf2; higher expression levels of proteasomal protein subunits and increased proteasome peptidase activities. In line with these findings we noted that Hexapeptide-11 conferred significant protection in fibroblasts against oxidative-stress-mediated premature cellular senescence, while at in vivo skin deformation assays in human subjects it improved skin elasticity.
