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Product Description
2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), prepared from 2,6- dimethylaniline with thiophosgen, were added dropwise during 15 min to a well-stirred suspension of 15.0 g (0.2 mole) of 3-aminopropanol-1 in 100 ml of ether. The ether started to boil. Stirring under reflux was continued for 30 min, and the ether was then distilled off. The residue was treated with 100 ml of concentrated hydrochlor acid and boiled under reflux for 30 min. After cooling, it was diluted with water, filtered free from impurities, and the base was precipitated by the addition of concentrated sodium hydroxid solution. When recrystallized from benzene-ligroin, the resulting compound 2-(2,6- dimethyl-phenylamino)-4H-5,6-dihydro-1,3-thiazine, melting point 140-142°C (yield 90% of the theoretical).
