Product Description

Pizotifen

Synonyms: 4-OXO-9,10-DIHYDRO-4H-BENZO(4,5) CYCLOHEPTO(1,2,B) THIOPHENE;PIZOTIFEN;4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine;BC 105;bc105;Litec;4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methyl-;4-(9,10-dihydro-4h-benzo(4,5)cyclohepta(1,2-b)thien-4-ylidene)-1-me
CAS: 15574-96-6
MF: C19H21NS
MW: 295.44
EINECS: 239-632-9

Chemical Properties White to Off-White Solid
Usage benzocycloheptane based drug
Usage Serotonin antagonist structurally related to Cyproheptadine. Antimigraine; appetite stimulant.

Pizotifen called new degree Semillon, pizotifen malate, is a chemical synthetic antihistamines, its chemical structure is similar cyproheptadine and amitriptyline, has strong anti 5- serotonin and histamine and weak anti acetylcholine effect, one of the commonly used drugs for the prevention of migraine.
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Application:
Pizotifen called new degree Semillon, pizotifen malate, is a chemical synthetic antihistamines, its chemical structure is similar cyproheptadine and amitriptyline, has strong anti 5- serotonin and histamine and weak anti acetylcholine effect, one of the commonly used drugs for the prevention of migraine.
1. This product is inhibition of bradykinin (BK) on the peripheral nerve pain induced sedation, and antidepressant effect.
2. This product can reduce the ethanol tolerance, can strengthen the tranquilizer, sedative and tricyclic antidepressant effect.
Clinical mainly for typical and atypical migraine, can relieve a symptom, reduce seizure frequency and duration, obvious curative effect on acute migraine, but no immediate relief, also be tried in erythromelalgia, angioneurotic edema, chronic urticaria, skin Nick disease etc...Another report, pizotifen for carcinoid syndrome caused by diarrhea and flushing, carotid pain, polycythemia induced pruritus.

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