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Product Description
Brief Description:GW0742 is one of the raw materials of SRAM. It is the enhanced type of GW501516 with good curative effect and little side effect. The quality is guaranteed and the price is favorable. Product link to :https://www.hkdmk.com/srams/99-purity-gw501516-cardarine-srams-for-sale.html Product Name: GW0742 CAS:317318-84-6 FW:C21H17F4NO3S2 MW:471.4846 Appearance: White powder Purity: 99.% min Package: 10g/bag or as customers'request. Test Method: HPLC Benefit:The effects of a high-affinity PPAR-?/? agonist, GW0742, in a mouse model of carrageenan (CAR)-induced pleurisy. Injection of CAR into the pleural cavity of mice elicited an acute inflammatory response characterized by accumulation of fluid containing a large number of neutrophils (polymorphonuclear leukocytes) in the pleural cavity, infiltration of polymorphonuclear leukocytes in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate, TNF-?, and IL-1?. Furthermore, CAR induced lung apoptosis (Bax and Bcl-2 expression), and nitrotyrosine formation was determined by immunohistochemical analysis of lung tissues. Administration of GW0742 (0.3 mg/kg, i.p. bolus) 30 min before and 30 min after a challenge with CAR caused a reduction in all the parameters of inflammation measured. Thus, based on these findings, we propose that a PPAR-?/? agonist such as GW0742 may be useful in the treatment of various inflammatory diseases.
